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Article

GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.

Molecular biology of the cell - 1 Feb 2009

Pai Chen Chun, García Ignacio, Wang Shao Win, Cotterill Sue, Macneill Stuart A, Kearsey Stephen E

Abstract excerpt

The tetrameric GINS complex, consisting of Sld5-Psf1-Psf2-Psf3, plays an essential role in the initiation and elongation steps of eukaryotic DNA replication, although its biochemical function is unclear. Here we investigate the function of GINS in fission yeast, using fusion of Psf1 and Psf2 subunits to a steroid hormone-binding domain (HBD) to make GINS function conditional on the presence of beta-estradiol. We...

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Identifiers

PMID: 19109429
DOI: 10.1091/mbc.e08-04-0429
PMCID: PMC2642745

Genes

HBD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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