Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of the GINS complex and functional insights into its role in DNA replication.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007

Chang Y Paul, Wang Ganggang, Bermudez Vladimir, Hurwitz Jerard, Chen Xiaojiang S

Abstract excerpt

The GINS complex, which contains the four subunits Sld5, Psf1, Psf2, and Psf3, is essential for both the initiation and progression of DNA replication in eukaryotes. GINS associates with the MCM2-7 complex and Cdc45 to activate the eukaryotic minichromosome maintenance helicase. It also appears to interact with and stimulate the polymerase activities of DNA polymerase epsilon and the DNA polymerase alpha-primase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Proteins, Non-Histone
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Protein Folding

Share to Protein Structure, Quaternary

Share to Protein Subunits

Share to Structural Homology, Protein

Share to Sulfolobus solfataricus

Source

Open in PubMed Open full text

Identifiers

PMID: 17652513
DOI: 10.1073/pnas.0705558104
PMCID: PMC1937527

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of the GINS complex and functional insights into its role in DNA replication.PMID 17652513Read ↗

GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.Semantic proximity Read ↗

Human GINS : a conserved DNA replication factor and candidate cancer markerSemantic proximity Read ↗

Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity.Semantic proximity Read ↗

Drosophila Psf2 has a role in chromosome condensation.Semantic proximity Read ↗

Structural study of the N-terminal domain of human MCM8/9 complex.Semantic proximity Read ↗

Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.Semantic proximity Read ↗

The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break RepairSemantic proximity Read ↗

Treslin and its role in the assembly of the replicative DNA helicaseSemantic proximity Read ↗

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteinsSemantic proximity Read ↗

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.Semantic proximity Read ↗

Complexed crystal structure of replication restart primosome protein PriB reveals a novel single-stranded DNA-binding mode.Semantic proximity Read ↗

Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.