Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.

doi:10.1073/pnas.1207673110

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Article

Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012

Weng Meng-Tzu, Lee Jih-Hsiang, Wei Shu-Chen, Li Qiuning, Shahamatdar Sina, Hsu Dennis, Schetter Aaron J, Swatkoski Stephen, Mannan Poonam, Garfield Susan, Gucek Marjan, Kim Marianne K H, Annunziata Christina M, Creighton Chad J, Emanuele Michael J, Harris Curtis C, Sheu Jin-Chuan, Giaccone Giuseppe, Luo Ji

Abstract excerpt

Cancers with Ras mutations represent a major therapeutic problem. Recent RNAi screens have uncovered multiple nononcogene addiction pathways that are necessary for the survival of Ras mutant cells. Here, we identify the evolutionarily conserved gene enhancer of rudimentary homolog (ERH), in which depletion causes greater toxicity in cancer cells with mutations in the small GTPase KRAS compared with KRAS WT cells....

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Identifiers

PMID: 23236152
DOI: 10.1073/pnas.1207673110
PMCID: PMC3535619

Genes

ERH
KRAS
SNRPD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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