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Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNA

2022-07-05

Abstract excerpt

<h4> Abstract </h4> Plasma cell-free DNA (cfDNA) methylation and fragmentation signatures have been shown to be valid biomarkers for blood-based cancer detection. However, conventional methylation sequencing assays are inapplicable for fragmentomic profiling due to bisulfite-induced DNA damage. Here using enzymatic conversion-based low-pass whole-methylome sequencing (WMS), we developed a novel approach to compr...

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Literature Corpus work
a6bb2e36-cbd8-5855-88be-0ee899c75ddd
DOI
10.1101/2022.07.04.498641
Open publication

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Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNADOI 10.1101/2022.07.04.498641
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