Article

Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regions

2024-02-07

Abstract excerpt

Cell-free DNA (cfDNA) has shown promise as a non-invasive biomarker for cancer screening and monitoring. The current advanced machine learning (ML) model, known as DNA evaluation of fragments for early interception (DELFI), utilizes the short and long fragmentation pattern of cfDNA and has demonstrated exceptional performance. However, the application of cfDNA-based model can be limited by the high cost of whole-g...

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Literature Corpus work: 90a7c9e1-1fe0-5409-86ca-3604449f0bff
DOI: 10.1101/2024.02.06.24302178

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