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TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers

15 Jul 2024

Abstract excerpt

BACKGROUND: Detection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we proposed a plasma cfDNA-based approach called TOTEM to detect and trace the cancer signal origin (CSO) through methylation markers. METHODS: We performed enzymatic conversion-based targeted methylation sequencing on plasma cfDNA samples collected from a clinical cohort of...

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Cancer Genomics and Diagnostics
Epigenetics and DNA Methylation
Multiple and Secondary Primary Cancers

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39009999
DOI: 10.1186/s12885-024-12626-7

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