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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

30 Mar 2020

Abstract excerpt

BACKGROUND: Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and localize multiple cancer types across all stages at high specificity. PARTICIPANTS AND METHODS: The 6689...

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PMID: 33506766
DOI: 10.1016/j.annonc.2020.02.011

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