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GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing

5 Jun 2025

Abstract excerpt

BACKGROUND: Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival. To address this clinical need, we developed GutSeer, a blood-based assay combining DNA methylation and fragmentomics for multi-GI cancer detection. METHODS: Genome-wide methylome profiling identified 1,656 markers...

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Cancer Genomics and Diagnostics
Epigenetics and DNA Methylation
Esophageal Cancer Research and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40468355
DOI: 10.1186/s12943-025-02367-x

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