Article

Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection

2025-10-21

Abstract excerpt

Liquid biopsy offers a minimally invasive opportunity to detect and monitor cancers through analysis of cell-free DNA (cfDNA). However, current approaches face challenges of limited sensitivity at low tumor fractions, technical variability, and poor generalization across cohorts. Tumor-informed targeted methods offer high specificity but suffer from low sensitivity due to random sampling, tumor evolution and adapt...

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Literature Corpus work: 9191f052-8809-5af1-992a-527e982e3f22
DOI: 10.1101/2025.10.20.683167

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