Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers

Abstract excerpt

<title>Abstract</title> <p><bold>DNA methylation is an extensively studied, stable, and fundamental epigenetic alteration in most cancer types</bold>^{<bold>1</bold>}<bold>. Single-base-pair resolution analyses of DNA methylation is currently feasible</bold>^{<bold>2</bold>}<bold>. Analysis of DNA methylation, in liquid biopsies hold practice-changing potentials</bold>^{<bold>3-6</bold>}<b...

Topics

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• Cancer Cells and Metastasis
• Cancer Genomics and Diagnostics
• Epigenetics and DNA Methylation
• Genetic factors in colorectal cancer
• Lung Cancer Treatments and Mutations
• Pancreatic and Hepatic Oncology Research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

ac873bb3-685c-5d72-b2cc-7aa716e2ebe6

DOI

10.21203/rs.3.rs-3576016/v1