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Tuning T-cell immunological synapse by modular DNA-Nanobody engagers for precision immunotherapy

2026-07-23

Abstract excerpt

Bispecific T-cell engagers (TCEs) are a promising class of cancer immunotherapies, but their clinical use is limited by toxicity and insufficient specificity. Tuning the T cell– tumor interface through engager architecture may address these drawbacks. To this end, we engineered hybrid constructs composed of two nanobodies targeting CD3 and the model tumor antigen HER2, respectively, connected by rigid DNA linkers...

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Literature Corpus work
8ae07b92-636a-5d3d-a58f-0b5913eb6ba6
DOI
10.64898/2026.07.22.740045
Open publication

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Tuning T-cell immunological synapse by modular DNA-Nanobody engagers for precision immunotherapyDOI 10.64898/2026.07.22.740045
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