Article

Rational Tuning of CAR Tonic Signaling Yields Superior T-Cell Therapy for Cancer

2020-10-02

Abstract excerpt

<h4>SUMMARY</h4> Chimeric antigen receptors (CARs) are modular proteins capable of redirecting immune cells toward a wide variety of disease-associated antigens. Here, we explore the effects of CAR protein sequence and structure on CAR-T cell function. Based on the empirical observation that CD20 CARs with similar sequences exhibit divergent tonic-signaling and anti-tumor activities, we devised engineering strate...

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Literature Corpus work: 2c4e0785-693b-51ae-a9d4-80358b5f9879
DOI: 10.1101/2020.10.01.322990

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