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Article

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

1 Jan 2020

Abstract excerpt

Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects. In order to minimize off-target and on-target/off-tumor reactions, improve safety, enable controllability, provide high flexibility, and increase tumor specificity, we established a novel humanized artificial receptor platform termed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32923149
DOI: 10.1080/2162402x.2020.1785608

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