Article

VEGFA’s distal enhancer regulates its alternative splicing in CML

2021-01-10

Abstract excerpt

Enhancer demethylation in leukemia and lymphoma was shown to lead to overexpression of genes which promote cancer characteristics. The vascular endothelial growth factor A (VEGFA) enhancer, located 157 Kb downstream of its promoter, is demethylated in chronic myeloid leukemia (CML). VEGFA has several alternative splicing isoforms with different roles in vascularization and cancer progression. Since transcription a...

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Literature Corpus work: a682f458-782c-5576-8f82-34ce71dad63c
DOI: 10.1101/2021.01.09.426072

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