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Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia

22 Dec 2016

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by an impaired differentiation process leading to an accumulation of immature blasts in the blood. One feature of cytogenetically normal AML is alterations to the DNA methylome. We analyzed 57 AML patients with normal karyotype by using Illumina's 450k array and showed that aberrant DNA methylation is significantly altered at enhancer regions and that the methylation...

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Identifiers

PMID: 28003272
DOI: 10.1182/blood-2016-07-726877

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