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Leukemia Risk Factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression

2025-10-17

Abstract excerpt

Multiple genetic association studies linked variants at ARID5B with predisposition to B-cell derived acute lymphoblastic leukemia (B-ALL) in children. Still, the molecular function of ARID5B remains largely uncharacterized. Here, we employ a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2...

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Literature Corpus work
8df58971-4b79-5634-a0be-0d80ad953f8c
DOI
10.1101/2025.10.17.683040
Open publication

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Leukemia Risk Factor ARID5B Coordinates HDAC-Mediated Transcriptional RepressionDOI 10.1101/2025.10.17.683040
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