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Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia

19 Jun 2024

Abstract excerpt

Mutations in the FOXF1 gene, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, a lethal lung disease affecting newborns and infants. Identification of new FOXF1 upstream regulatory elements is critical to explain why frequent non-coding FOXF1 deletions are linked to the disease. Herein, we use multiome single-nuclei RNA and...

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PMID: 38898031
DOI: 10.1038/s41467-024-49477-6

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Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasiaPMID 38898031Read ↗

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