Article

<i>ETV6</i> Deficiency and Microsatellite Enhancers Drive Transcriptional Dysregulation in B-Lymphoblastic Leukemia

2022-09-21

Abstract excerpt

Distal enhancers play critical roles in sustaining oncogenic gene expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature of B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects of the ETV6 transcriptional repressor, including ETV6-RUNX1 + and ETV6 -null B-ALL. We show that GGAA repeat enhancers are direct activators of previously identif...

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Literature Corpus work: 216afecf-c241-5d4c-8deb-cba4ae8b3d66
DOI: 10.1101/2022.09.20.508499

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