Article
MYC enhancer invasion promotes prognostic cancer type-specific gene programs through an epigenetic switch
2023-01-07
Abstract excerpt
The transcription factor MYC is overexpressed in most cancers, where it drives multiple hallmarks of cancer progression. MYC is known to promote oncogenic transcription by binding to active promoters. In addition, MYC has also been shown to invade distal enhancers when expressed at oncogenic levels, but this enhancer binding has been proposed to have low gene-regulatory potential. Here, we demonstrate that MYC enh...
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Identifiers and source
- Literature Corpus work
- 21f23129-2e64-522c-a37e-d504adef32e4
- DOI
- 10.1101/2023.01.06.522970