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Article

Enhancer dysfunction in leukemia.

Blood - 19 Apr 2018

Bhagwat Anand S, Lu Bin, Vakoc Christopher R

Abstract excerpt

Hematopoietic cancers are often initiated by deregulation of the transcriptional machinery. Prominent among such regulators are the sequence-specific DNA-binding transcription factors (TFs), which bind to enhancer and promoter elements in the genome to control gene expression through the recruitment of cofactors. Remarkably, perturbing the function of even a single TF or cofactor can modulate the active enhancer...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29439951
DOI: 10.1182/blood-2017-11-737379
PMCID: PMC5909760

Genes

TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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