Article

Cell-type-specific transcriptomic signatures associated with Alzheimer’s disease in the ROSMAP cohort: a single-nucleus RNA-seq pseudobulk analysis.

2026-01-06

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder involving interactions between neuronal, glial, and vascular processes. While single-cell and single-nucleus RNA sequencing studies have identified cell-type-specific transcriptional alterations in AD, the extent to which these patterns are consistently associated with disease status at the donor level remains...

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Literature Corpus work: 820963d1-494e-56dd-b9c2-b6fce5bfc68e
DOI: 10.21203/rs.3.rs-8475138/v1

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