Article

Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer’s Disease and aged human brain

2022-07-14

Abstract excerpt

<title>Abstract</title> <p>Microglia contribute to Alzheimer’s Disease (AD) progression and are candidate therapeutic targets for disease modulation. Single cell transcriptomics demonstrate microglia adopt multiple phenotypes. However, identifying the human AD microglia profile was limited by small numbers. We employed fluorescence activated nuclei sorting prior to single-nucleus RNA-seq on human prefrontal corti...

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Literature Corpus work: d8b5b4f7-cebe-54b3-aa25-96e44e962872
DOI: 10.21203/rs.3.rs-1836861/v1

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