Article

The molecular landscape of polycystic kidneys is marked by common alterations in purine metabolism

2025-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Cysts develop through dedifferentiation of tubular epithelial cells, but the sequence of molecular events and their relative importance remain unclear. To address this gap in knowledge, 40 cysts from 4 ADPKD kidneys and 4 microcystic tissues were mapped on transcriptomic and histological level. Cyst...

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Literature Corpus work: 64275f0d-9012-5d2b-94a5-5eed4323560b
DOI: 10.1101/2025.08.07.668867

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