Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease

Abstract excerpt

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common monogenic kidney disease worldwide. Tolvaptan is currently the only approved intervention to slow kidney cyst growth, but its indication is limited to rapidly progressing ADPKD and use compromises quality of life. Hence, new therapeutic options are of high clinical importance. Metabolic dysregulation is a hallmark of kidney cyst growth, includ...

Topics

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• Energy Metabolism
• Kidney
• Metabolome
• Metabolomics
• Mice, Mutant Strains
• Polycystic Kidney, Autosomal Dominant
• Tandem Mass Spectrometry
• TRPP Cation Channels

Identifiers and source

Literature Corpus work

47b4ff4f-2ae9-5b87-8b49-17322f16f915

DOI

10.64898/2026.06.02.729335