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AMD1-Mediated Polyamine Metabolism Governs Tubular Repair Fate by Restraining Senescence after Kidney Injury

2026-03-09

Abstract excerpt

<title>Abstract</title> <p>Failure of adaptive repair after acute kidney injury (AKI) drives the transition to chronic kidney disease (CKD), yet the metabolic checkpoints governing tubular fate remain incompletely defined. Here, we investigated whether the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase 1 (SAMD1/AMD1) regulates tubular senescence and repair outcomes after kidney injury and elucid...

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Literature Corpus work
ebe196c8-0e9f-550f-9e15-4a374ce20293
DOI
10.21203/rs.3.rs-8957509/v1
Open publication

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