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Article

Meta-analysis of polycystic kidney disease expression profiles defines strong involvement of injury repair processes.

American journal of physiology. Renal physiology - 1 Apr 2017

Malas Tareq B, Formica Chiara, Leonhard Wouter N, Rao Pooja, Granchi Zoraide, Roos Marco, Peters Dorien J M, 't Hoen Peter A C

Abstract excerpt

Polycystic kidney disease (PKD) is a major cause of end-stage renal disease. The disease mechanisms are not well understood and the pathogenesis toward renal failure remains elusive. In this study, we present the first RNASeq analysis of a Pkd1-mutant mouse model in a combined meta-analysis with other published PKD expression profiles. We introduce the PKD Signature, a set of 1,515 genes that are commonly...

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Identifiers

PMID: 28148532
DOI: 10.1152/ajprenal.00653.2016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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