Article

Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

2021-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derangement using two mouse models of PKD1 mutation, PKD1 RC/null and PKD1 RC/RC . Mouse kidneys with PKD1 mutation have decreased mitochondrial complexes activity. Targeted proteomics analysis...

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Literature Corpus work: a877073a-408b-5b97-88bd-49602449f9cf
DOI: 10.1101/2021.09.15.460510

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