Article

Commensal-derived succinate enhances tuft cell specification and suppresses ileal inflammation

2019-09-20

Abstract excerpt

Longitudinal analysis of Crohn's disease (CD) incidence has identified an inverse correlation with helminth infestation and recent studies have revealed that intestinal tuft cell hyperplasia is critical for helminth response. Tuft cell frequency was decreased in the inflamed ilea of CD patients and a mouse model of TNFα-induced Crohn's-like ileitis (TNFΔARE). Single-cell RNA sequencing paired with unbiased differe...

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Literature Corpus work: a610daff-2029-5f77-9b1b-5ff9a90f713b
DOI: 10.1101/776724

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