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Article

Inflammation-induced epigenetic imprinting regulates intestinal stem cells

3 Sept 2024

Abstract excerpt

It remains unknown whether and how intestinal stem cells (ISCs) adapt to inflammatory exposure and whether the adaptation leaves scars that will affect their subsequent regeneration. We investigated the consequences of inflammation on Lgr5 + ISCs in well-defined clinically relevant models of acute gastrointestinal graft-versus-host disease (GI GVHD). Utilizing single-cell transcriptomics, as well as organoid,...

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PMID: 39232559
DOI: 10.1016/j.stem.2024.08.006

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