Article

Excess dietary sugar impairs colonic epithelial regeneration in response to damage

2021-08-19

Abstract excerpt

The colonic epithelium requires continuous renewal by intestinal stem cells (ISCs) to restore the barrier after damage and proliferation of epithelial cells is modulated by dietary metabolites. We demonstrate that mice fed a high sugar diet failed to repair colonic barrier damage, resulting in increased intestinal pathology. Culturing ISCs in excess sugar limited murine and human colonoid development, indicating t...

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Identifiers and source

Literature Corpus work: 058c5fcb-357c-5345-b495-257b97f4d72f
DOI: 10.1101/2021.08.18.456840

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