Article

Inflammatory memory restrains intestinal stem cell regeneration

2023-03-07

Abstract excerpt

<title>Abstract</title> <p>Intestinal stem cells (ISC) encounter inflammatory insults in immune mediated gastro-intestinal (GI) diseases. It remains unknown whether, and how, they adapt, and if the adaptation leaves scars on the ISCs that affects their subsequent regeneration capacity. We investigated the consequences of inflammation on Lgr5<sup>+</sup>ISCs in well-defined clinically relevant models of gastro-int...

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Literature Corpus work: 9327c24c-d163-5e10-a25e-dfc3007d1e52
DOI: 10.21203/rs.3.rs-2566520/v1

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