Article

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

2023-07-27

Abstract excerpt

<h4>Summary</h4> Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBD). To understand how microbial-metabolic circuits contribute to intestinal tissue injury, we disrupt mitochondrial function in the epithelium by deleting heat shock protein 60 (Hsp60 Δ/ΔIEC ). While metabolic perturbation causes self-resolving tissue injury, regeneration is disrupted in the absence of aryl hydrocarbon r...

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Literature Corpus work: b543911c-1864-582c-858d-25c5ab0995c9
DOI: 10.1101/2023.07.27.549844

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