Article

Investigating intestinal epithelium metabolic dysfunction in Celiac Disease using personalized genome-scale models

2024-05-01

Abstract excerpt

Celiac Disease (CeD) is an autoimmune condition characterized by an aberrant immune response triggered by the ingestion of gluten, which damages epithelial cells lining the small intestine. Small intestinal epithelial cells (sIECs) play a key role in various metabolic processes, including the enzymatic digestion and absorption of nutrients. Although nutritional malabsorption is widely recognized in CeD, the underl...

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Literature Corpus work: 70f5fa2c-0182-5ae1-abd3-0bbf10bfa2d9
DOI: 10.1101/2024.04.29.591234

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