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Article

Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease

16 Jun 2012

Abstract excerpt

Huntington disease (HD) is caused by an extended polyglutamine [poly(Q)] stretch in the Huntingtin (HTT) protein, and is associated with the accumulation of intracellular protein aggregates, onset of progressive chorea, psychiatric symptoms and dementia. Although the mechanism underlying the pathological effects of mutant HTT (mHTT) remains highly controversial, accumulating evidence suggest that protein-folding...

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PMID: 22617512
DOI: 10.4161/auto.20139

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