Article

Poly (ADP-ribose) induces α-synuclein aggregation in neuronal-like cells and interacts with phosphorylated α-synuclein in post mortem PD samples

2020-04-09

Abstract excerpt

<h4>Background</h4> Poly (ADP-ribose) (PAR) is a negatively charged polymer that is biosynthesized by Poly (ADP-ribose) Polymerase-1 (PARP-1) and regulates various cellular processes. Alpha-synuclein (αSyn) is an intrinsically disordered protein (IDP) that has been directly implicated with driving the onset and progression of Parkinson’s disease (PD). The mechanisms by which αSyn elicits its neurotoxic effects re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48fcffd6-0884-5233-a764-c0fda1f9e283
DOI: 10.1101/2020.04.08.032250

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Poly (ADP-ribose) induces α-synuclein aggregation in neuronal-like cells and interacts with phosphorylated α-synuclein in post mortem PD samplesDOI 10.1101/2020.04.08.032250Read

Poly ADP-Ribose Signaling is Dysregulated in Huntington DiseaseSemantic proximity Read

Poly (ADP-ribose) in the pathogenesis of Parkinson's diseaseSemantic proximity Read

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.Semantic proximity Read

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer’s Disease ModelSemantic proximity Read

Poly ADP-ribose signaling is dysregulated in Huntington diseaseSemantic proximity Read

Selective Inhibition of Cytosolic PARylation via PARG99: A Targeted Approach for Mitigating FUS-associated NeurodegenerationSemantic proximity Read

A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.Semantic proximity Read

Methods for detecting toxic α-synuclein species as a biomarker for Parkinson’s diseaseSemantic proximity Read

Widespread Distribution of α-Synuclein Oligomers in <i>LRRK2</i> -related Parkinson’s DiseaseSemantic proximity Read

Parkinson’s Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein ClearanceSemantic proximity Read

Oligomers of α-synuclein: picking the culprit in the line-up.Semantic proximity Read

Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradationSemantic proximity Read