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Article

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease

16 Dec 2010

Abstract excerpt

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) is the main event leading to the induction of the ER stress-related unfolded protein response (UPR). Recent postmortem evaluation, showing that the UPR pathway is activated in nigral dopaminergic neurons bearing α-synuclein inclusions in the brain of Parkinson's disease (PD) patients, suggests that the activation of the UPR may be induced by the...

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PMID: 21166675
DOI: 10.1111/j.1471-4159.2010.07143.x

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