Article

Sephin1 rewires proteostasis through actin-dependent signaling

2026-04-21

Abstract excerpt

The maintenance of protein homeostasis is vital for all cells. Alteration in protein handling underlies several diseases. The small molecule sephin1 is a promising clinical candidate against proteostasis disruption, but its mechanism of action is still uncertain. Our experimental evidence shows that sephin1 binds G-actin and drives actin cytoskeleton misfolding, and eventually, Golgi disintegration. At first, seph...

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Literature Corpus work: 58b11429-be90-5d64-b40c-d49ac4fe9ceb
DOI: 10.64898/2026.04.20.719601

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