Article
Probing the structure of the HIV-1 Rev trans-activator protein by functional analysis.
Protein engineering - 1 Feb 1997
Thomas S L, Hauber J, Casari G
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) encodes a trans-acting regulatory protein, termed Rev, which is critically required for virus replication. Rev is a sequence-specific RNA binding protein which mediates the nuclear export of unspliced and incompletely spliced viral mRNAs encoding the vi...
Topics
- Animals
- Binding Sites
- COS Cells
- Gene Products, rev
- HIV-1
- Humans
- Models, Molecular
- Molecular Structure
- Mutagenesis, Site-Directed
- Phenotype
- Protein Conformation
- Protein Engineering
- rev Gene Products, Human Immunodeficiency Virus