Article
Analysis of nuclear targeting activities of transport signals in the human immunodeficiency virus Rev protein.
Experimental cell research - 10 Dec 2003
Demart Séverine, Ceccherini-Silberstein Francesca, Schlicht Stefan, Walcher Sebastian, Wolff Horst, Neumann Markus, Erfle Volker, Brack-Werner Ruth
Abstract excerpt
The human immunodeficiency Rev protein shuttles between the nucleus and cytoplasm, while accumulating to high levels in the nucleus. Rev has a nuclear localization signal (NLS; AA 35-50) with an arginine-rich motif (ARM) that interacts with importin beta and a leucine-rich nuclear export signal (NES; AA 75-84) recognized by CRM1/exportin 1. Here we explore nuclear targeting activities of the transport signals of...
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