Article
Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction.
Nucleic acids research - 20 Jun 2025
Ojha Manju, Hudson Lucia, Photenhauer Amanda, Zang Trinity, Lerew Lauren, Ekesan Şölen, Daniels Jason, Nguyen Megan, Paudyal Hardik, York Darrin M, Ohi Melanie D, Marchant Jan, Bieniasz Paul D, Koirala Deepak
Abstract excerpt
The Rev response element (RRE) forms an oligomeric complex with the viral protein Rev to facilitate the nuclear export of intron-retaining viral RNAs during the late phase of HIV-1 (human immunodeficiency virus type 1) infection. However, the structures and mechanisms underlying this process remain largely unknown. Here, we determined the crystal structure of the HIV-1 RRE stem-loop II (SLII), revealing a unique...
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