Article
Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.
Journal of virology - 1 Nov 1998
Bogerd H P, Echarri A, Ross T M, Cullen B R
Abstract excerpt
The hypothesis that the cellular protein Crm1 mediates human immunodeficiency virus type 1 (HIV-1) Rev-dependent nuclear export posits that Crm1 can directly interact both with the Rev nuclear export signal (NES) and with cellular nucleoporins. Here, we demonstrate that Crm1 is indeed able to int...
Topics
- Animals
- Biological Transport, Active
- Carrier Proteins
- Cell Line
- Cell Nucleus
- Cytoplasm
- Gene Expression
- Gene Products, rev
- Genes, Viral
- HIV Infections
- HIV-1
- Human T-lymphotropic virus 1
- Humans
- Karyopherins