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Article

A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.

Cellular and molecular life sciences : CMLS - 1 Dec 2016

García-Santisteban Iraia, Arregi Igor, Alonso-Mariño Marián, Urbaneja María A, Garcia-Vallejo Juan J, Bañuelos Sonia, Rodríguez Jose A

Abstract excerpt

The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms underlying CRM1/NES interaction. CRM1 binds NESs through a hydrophobic cleft, whose open or closed conformation facilitates NES binding and release. Several cofactors allosterically modulate the...

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Source

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Identifiers

PMID: 27312238
DOI: 10.1007/s00018-016-2292-0
PMCID: PMC11108298

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.PMID 27312238Read ↗

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