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Article

A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis.

Biological psychiatry - 1 Jul 2024

Zeng Lu, Fujita Masashi, Gao Zongmei, White Charles C, Green Gilad S, Habib Naomi, Menon Vilas, Bennett David A, Boyle Patricia, Klein Hans-Ulrich, De Jager Philip L

Abstract excerpt

BACKGROUND: Depression, a common psychiatric illness and global public health problem, remains poorly understood across different life stages, which hampers the development of novel treatments. METHODS: To identify new candidate genes for therapeutic development, we performed differential gene expression analysis of single-nucleus RNA sequencing data from the dorsolateral prefrontal cortex of older adults (n =...

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Identifiers

PMID: 38141910
DOI: 10.1016/j.biopsych.2023.12.012
PMCID: PMC11168890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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