Shared genetic architecture across psychiatric disorders.

Abstract excerpt

Psychiatric disorders overlap substantially at the genetic level, with family-based methods long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed rapidly in the last decade, shedding light on the biological makeup of cross-disorder risk at multiple levels of analysis. Over a hundred genetic variants have been identified that affect multiple disorders, with many more to be...

Topics

• Comorbidity
• Genome-Wide Association Study
• Genomics
• Humans
• Mental Disorders
• Multifactorial Inheritance
• Mutation
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors