Article

Long-term prevention of aneuploidy in human pluripotent stem cells by fine-tuning GSK3 activity

2025-10-27

Abstract excerpt

<h4>Summary</h4> Human pluripotent stem cells (hPSCs) are critical cell sources to model human development and hold promise towards regenerative medicine. However, cultured hPSCs quickly acquire chromosome gains or losses (aneuploidy) due to high replicative stress and errors in chromosome segregation, which hampers their use for stem cell therapies. We have recently described that embryo patterning signals contr...

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Literature Corpus work: f1e165f6-d1a7-542b-84a1-e13f634940be
DOI: 10.1101/2025.10.27.684724

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