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Article

MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities

1 Mar 2020

Abstract excerpt

Tumors that overexpress the MYC oncogene are frequently aneuploid, a state associated with highly aggressive cancers and tumor evolution. However, how MYC causes aneuploidy is not well understood. Here, we show that MYC overexpression induces mitotic spindle assembly defects and chromosomal instability (CIN) through effects on microtubule nucleation and organization. Attenuating MYC expression reverses mitotic...

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PMID: 32160543
DOI: 10.1016/j.celrep.2020.02.041

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