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Article

The broad role of Nkx3.2 in the development of the zebrafish axial skeleton.

PloS one - 1 Jan 2021

Waldmann Laura, Leyhr Jake, Zhang Hanqing, Öhman-Mägi Caroline, Allalou Amin, Haitina Tatjana

Abstract excerpt

The transcription factor Nkx3.2 (Bapx1) is an important chondrocyte maturation inhibitor. Previous Nkx3.2 knockdown and overexpression studies in non-mammalian gnathostomes have focused on its role in primary jaw joint development, while the function of this gene in broader skeletal development is not fully described. We generated a mutant allele of nkx3.2 in zebrafish with CRISPR/Cas9 and applied a range of...

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Identifiers

PMID: 34411150
DOI: 10.1371/journal.pone.0255953
PMCID: PMC8376051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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