Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1.

Genetics - 1 Sept 2003

Kokubu Chikara, Wilm Bettina, Kokubu Tomoko, Wahl Matthias, Rodrigo Isabel, Sakai Norio, Santagati Fabio, Hayashizaki Yoshihide, Suzuki Misao, Yamamura Ken-Ichi, Abe Kuniya, Imai Kenji

Abstract excerpt

Previous studies have indicated that the Undulated short-tail deletion mutation in mouse Pax1 (Pax1(Un-s)) not only ablates Pax1, but also disturbs a gene or genes nearby Pax1. However, which gene(s) is involved and how the Pax1(Un-s) phenotype is confined to the Pax1-positive tissues remain unkn...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Mice, Transgenic

Share to Paired Box Transcription Factors

Share to Sequence Deletion

Share to Transcription Initiation Site

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 14504237
DOI: 10.1093/genetics/165.1.299
PMCID: PMC1462742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14504237-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1.PMID 14504237Read ↗

Loss of Nkd1 is epistatic to loss of Axin2 in regulating Wnt signalingSemantic proximity Read ↗

undulated phenotypes suggest a role of Pax-1 for the development of vertebral and extravertebral structures.Semantic proximity Read ↗

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.Semantic proximity Read ↗

The role of Pax-1 in axial skeleton development.Semantic proximity Read ↗

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.Semantic proximity Read ↗

Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency.Semantic proximity Read ↗

Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.Semantic proximity Read ↗

Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx.Semantic proximity Read ↗

Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting.Semantic proximity Read ↗

Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.Semantic proximity Read ↗

Transcription factors Nkx3.1 and Nkx3.2 (Bapx1) play an overlapping role in sclerotomal development of the mouse.Semantic proximity Read ↗

Temporal misexpression of <i>En1</i> during limb development causes distinct phenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.