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Article

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.

Molecular and cellular biology - 1 Jun 2007

Zhang Shu, Cagatay Tolga, Amanai Manami, Zhang Mei, Kline Janine, Castrillon Diego H, Ashfaq Raheela, Oz Orhan K, Wharton Keith A

Abstract excerpt

Gradients of Wnt/beta-catenin signaling coordinate development and physiological homeostasis in metazoan animals. Proper embryonic development of the fruit fly Drosophila melanogaster requires the Naked cuticle (Nkd) protein to attenuate a gradient of Wnt/beta-catenin signaling across each segmental anlage. Nkd inhibits Wnt signaling by binding the intracellular protein Dishevelled (Dsh). Mice and humans have two...

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Identifiers

PMID: 17438140
DOI: 10.1128/MCB.00133-07
PMCID: PMC1900041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.PMID 17438140Read ↗

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