Article
Genetic analysis of attractin homologs.
Genesis (New York, N.Y. : 2000) - 1 Dec 2007
Walker Will P, Aradhya Swaroop, Hu Che-Lin, Shen Shiliang, Zhang Wei, Azarani Arezou, Lu XinYun, Barsh Gregory S, Gunn Teresa M
Abstract excerpt
Attractin (ATRN) and Attractin-like 1 (ATRNL1) are highly similar type I transmembrane proteins. Atrn null mutant mice have a pleiotropic phenotype including dark fur, juvenile-onset spongiform neurodegeneration, hypomyelination, tremor, and reduced body weight and adiposity, implicating ATRN in numerous biological processes. Bioinformatic analysis indicated that Atrn and Atrnl1 arose from a common ancestral gene...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Evolution, Molecular
- Membrane Proteins
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype
- Phylogeny
- Pigmentation